张大煜讲座(X):From Cosmic Chirality to Protein Structure: Lord Kelvin’s Legacy

报告时间:2012年10月22日(星期一)上午9:00

报告地点:生物楼学术报告厅

报告人:Prof. Laurence D. Barron

University of Glasgow

报告人简介:

英国格拉斯哥大学化学系教授,英国皇家学会院士,爱丁堡皇家学会院士。Barron教授主要致力于分子光、电、磁学性质的研究,特别是手性的研究,是国际上手性及其手性光谱学最权威的科学家。他在国际上首次报道了手性拉曼光谱,是手性拉曼光谱理论和实验的先驱。他撰写的“Molecular Light Scattering and Optical Activity”一书,成为国际上手性拉曼光谱理论和实验研究的经典著作。他的工作曾被Science, Nature, C&E NEWS等国际著名学术新闻刊物多次给予highlight。基于他在手性研究领域的杰出贡献,Barron教授获得意大利化学学会颁发的手性奖章等多种学术荣誉。

报告简介:

Chirality is a central and unifying theme in modern science. It links the properties of the universe and its constituent elementary particles, frozen in at the time of the big bang origin, through organic stereochemistry, to the structure and behaviour of the molecules of life, with much else besides (nonlinear optics, nanotechnology, materials, electrical engineering, pharmaceuticals, astrobiology, origin of life, etc.). Chirality has been a central theme of my research, and in this lecture I shall present an overview of some of the topics that I have found the most interesting and productive. There are two main themes:

1. Symmetry and Chirality will explain how the discrete symmetries of parity P, time reversal T and charge conjugation C may be used to characterize the properties of chiral systems. The concepts of true chirality (time-invariant enantiomorphism) and false chirality (time-noninvariant enantiomorphism) that emerge provide an extension of Lord Kelvin’s original definition of chirality to situations where motion is an essential ingredient thereby clarifying, inter alia, the nature of physical influences able to induce absolute enantioselection. Consideration of symmetry violations reveals that strict enantiomers (exactly degenerate) are interconverted by the combined CP operation.

2. Raman Optical Activity (ROA) will survey work, from first observation to current applications, on a new chiroptical spectroscopy that measures vibrational optical activity via Raman scattering of circularly polarized light. ROA provides incisive information ranging from absolute configuration and complete solution structure of smaller chiral molecules and oligomers to protein and nucleic acid structure of intact viruses.

联系人:杨绿娟 贾国卿(9302)

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